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A Newsletter Exploring
Biomedical Research Issues For Middle & High School Educators

Vol. 1, Issue 6, Fall 2003

BioFocus Logo

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Focus
NOTEWORTHY PATHOLOGISTS

Peter C. Doherty
Shared the 1996 Nobel Prize for his work on the cellular immune response to viral infections. The knowledge provides a better platform for the construction of new vaccines. Dr. Doherty is an Australian veterinarian who currently does his research at St. Jude's Children's Hospital in Memphis, Tennessee. His autobiography is on the Nobel website and is a very good read.

Tracey McNamara
Dr. McNamara is head pathologist at the Bronx Zoo in New York and was the first to recognize West Nile virus. Read her story.

SOCIETY OF TOXICOLOGY

The society has a very informative website offering excellent materials and public outreach programs, including "Paracelsus Goes to School", workshops for K-12 teachers.


Spotlight on Michigan Pathologist

Dr. CrissmanDr. Crissman, who contributed the article on the front page, works as a toxicologic veterinary pathologist for Dow Corning. He attended undergraduate and veterinary school at Michigan State, and, after a manure-covered year in a dairy cow practice in Ohio, did his pathology residency and graduate training at Cornell University in Ithaca, NY. He has published more than twenty scientific journal articles as well as a small book of poems titled Jailbait in Holy Water. He grew up as one of eight kids on a farm near Caledonia, Michigan, where he was active in 4-H and showed beef cattle and sheep. Jim is an avid bicyclist, both road and mountain bikes, and is largely responsible for the mountain bike singletrack in the Midland City Forest. He also loves crosscountry and downhill skiing, fly fishing, bow hunting, and writing. Jim and his wife, Dr. Jill Haver-Crissman, also a veterinarian, have three children and live on a small farm near Midland with assorted horses, dogs, cats, and the odd amphibian held captive by their youngest.


A Few Pathology & Toxicology Terms
By James W. Crissman, D.V.M., Ph.D.

Pathology: The study of the structural or functional changes in the body that cause or are caused by disease.

Lesion: Any pathological change in the structure or function of a body part.

Biopsy: The removal and examination of tissue (usually microscopic) to establish a diagnosis.

Cancer: An abnormal proliferation of cells, which may originate in any tissue, and which in its natural unchecked course, will kill the host. Many cancers can now be treated effectively, especially if discovered early.

Malignant & Benign: These words are used to describe many pathologic processes, but especially tumors. Benign tumors grow slowly in place and often may be easily removed or even sometimes ignored. Malignant tumors are cancerous; they spread by local invasion or metastasis to other parts of the body. The line between benign and malignant is not always clear, and some benign tumors can become malignant.

Autopsy/Necropsy: The post mortem (after death) examination of a body to characterize disease processes or traumatic injuries, especially to determine the cause of death. The term autopsy is used for humans (auto = self); necropsy is used for animals.

Toxicology: The scientific study of the toxic properties of natural and synthetic chemicals. This includes learning what happens in the body at high dose levels and what dose is harmless.

Paracelsus: (1493—1541) Swiss physician and alchemist, and perhaps the father of modern toxicology. He is most remembered for this fundamental principle: "What is it that is not poison? All things are poison and nothing is without poison. It is only the dose that makes a thing not a poison." Or, as your mother might say: "All things in moderation, dear."


BioFocus
Biofocus is published by the Michigan Society for Medical Research. Please send your questions, comments, and suggestions to:

MISMR
P.O. Box 3237
Ann Arbor, MI 48106-3237
Voice: (734) 763-8029
Fax: (734) 930-1568
Email: MISMR@umich.edu


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MISMR members strongly support humane animal study in research. We hope that likeminded citizens will join us in working for rational public policy that assures the continued appropriate use of animals in the course of good science.